Structural Basis for the Recognition and removal of damaged bases from DNA by a DNA Repair Enzyme, 3-Methyladenine DNA glycosylase from Escherichia coli.

• YAMAGATA Yuriko

  大阪大学薬学部

Bibliographic Information

Other Title

• 大腸菌由来ＤＮＡ修復酵素３‐メチルアデニンＤＮＡグリコシラーゼの構造と機能
• ダイチョウキン ユライ DNA シュウフク コウソ 3 メチルアデニン DNA

Abstract

Escherichia coli 3-methyladenine DNA glycosylase II is a DNA repair enzyme that removes numerous alkylated bases from DNA. The three-dimensional structure, mutagenesis and model building studies suggest that the active site is located in a cleft between the two helical domains and that the enzyme flips the target base out of the DNA duplex into the active-site cleft. The structural similarity among a variety of DNA glycosylases shows the existence of a DNA glycosylase family, whose members recognize diverse sets of substrates.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 39 (4), 303-308, 1997

  The Crystallographic Society of Japan

Details

• CRID: 1390282679064045184
• NII Article ID: 10002589822
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.39.303
• ISSN: 18845576
• ISSN: 03694585
• NDL BIB ID: 4292560
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4292560
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed