蛋白質構造解析法の最近の進歩 Recent Development of Structure Determination Methods for Protein Crystals
Recent development of crystal structure determination methods enables us to produce <I>ab initio</I> solution for protein crystals. Some such methods are based on reciprocal space direct methods and some of them employs real space density modification methods. One of most successful methods called Shake & Bake is a hybrid of reciprocal and real space methods. This article introduces recently developed methods which have been successfully applied to protein crystals.<BR>Although many methods described here require atomic resolution data, it is getting possible to collect high resolution data for standard protein crystals with development of data collection technique at low temperature and strong synchrotron X-ray source such as Spring-8.
日本結晶学会誌 40(5), 308-315, 1998-10-28
The Crystallographic Society of Japan