筋収縮を調節するしくみの解明に向けて-トロポニンC・トロポニンIフラグメント複合体の結晶構造 [in Japanese] Molecular Mechanism of Muscle Regulation-Structural Study of Troponin C in Complex with Troponin I Fragment [in Japanese]
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Troponin (Tn), the complex of three subunits (TnC, TnI and TnT), plays a key role in calcium-dependent regulation of striated muscle contraction. In order to elucidate the interactions between the Tn subunits, we have determined the crystal structure of TnC in complex with the N-terminal fragment of TnI (TnI<SUB>1-47</SUB>) at 2.3-angstrom resolution. The TnC/TnI<SUB>1-47</SUB> structure implies a mechanism of how Tn regulate the muscle contraction and suggests a unique a-helical regulatory TnI segment, which binds to the N-lobe of TnC in its calcium-bound comformation.
X-RAYS 40(6), 375-380, 1998-12-31
The Crystallographic Society of Japan