Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity
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An 18-peptide, T22, has been shown to have a strong anti-human immunodeficiency virus (HIV) activity comparable to that of 3′-azido-3′-deoxy-thymidine (AZT). Several shortened analogs of T22 were designed, synthesized and evaluated of their anti-HIV activities. A 14-peptide analog with one disulfide bond, TW70 (des-Cys<SUP>8,13</SUP>, Tyr<SUP>9,12</SUP>-[<FONT SIZE=-2>D</FONT>-Lys<SUP>10</SUP>, Pro<SUP>11</SUP>]-T22), showed comparable activity to that of T22, indicating that the molecular size of T22 could be reduced without loss of the activity.
- Chemistry Letters
Chemistry Letters 1996(7), 571-572, 1996-07
The Chemical Society of Japan