Irreversible Inactivation of Serine Proteases by Peptidyl α, β-Unsaturated Nitro Compounds
Peptidyl α,β-unsaturated nitro compounds were found to be active-site directed irreversible inhibitors of serine protease, α-chymotrypsin. The inactivation was selective because tripeptidyl derivative <B>4</B> did not show any irreversible inhibitory activity toward another serine protease, procine pancreatic elastase.
- Chemistry letters
Chemistry letters 1996(9), 789-790, 1996-09
The Chemical Society of Japan