Irreversible Inactivation of Serine Proteases by Peptidyl α,β-Unsaturated Nitro Compounds

• Tsuyoshi Ohba

  Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology

• Hisashi Takei

  Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology

抄録

Peptidyl α,β-unsaturated nitro compounds were found to be active-site directed irreversible inhibitors of serine protease, α-chymotrypsin. The inactivation was selective because tripeptidyl derivative 4 did not show any irreversible inhibitory activity toward another serine protease, procine pancreatic elastase.

収録刊行物

• Chemistry Letters

  Chemistry Letters 25 (9), 789-790, 1996-09-01

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360846644039376384
• NII論文ID: 10002606165
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.1996.789
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/25/9/789/56071161/cl.1996.789.pdf
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