Irreversible Inactivation of Serine Proteases by Peptidyl α, β-Unsaturated Nitro Compounds

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著者

    • OHBA Tsuyoshi
    • Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology
    • TAKEI Hisashi
    • Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology

抄録

Peptidyl α,β-unsaturated nitro compounds were found to be active-site directed irreversible inhibitors of serine protease, α-chymotrypsin. The inactivation was selective because tripeptidyl derivative <B>4</B> did not show any irreversible inhibitory activity toward another serine protease, procine pancreatic elastase.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1996(9), 789-790, 1996-09 

    The Chemical Society of Japan

参考文献:  8件

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各種コード

  • NII論文ID(NAID)
    10002606165
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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