Irreversible Inactivation of Serine Proteases by Peptidyl α,β-Unsaturated Nitro Compounds

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  • Tsuyoshi Ohba
    Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology
  • Hisashi Takei
    Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Peptidyl α,β-unsaturated nitro compounds were found to be active-site directed irreversible inhibitors of serine protease, α-chymotrypsin. The inactivation was selective because tripeptidyl derivative 4 did not show any irreversible inhibitory activity toward another serine protease, procine pancreatic elastase.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 25 (9), 789-790, 1996-09-01

    Oxford University Press (OUP)

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