Hydrophobilization of Lysozyme by Genetic Combination with Polyproline at the Carboxyl Terminal

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著者

    • ITO Yoshihiro
    • Department of Material Chemistry, Graduate School of Engineering, Kyoto Univeresity
    • HAMAMATSU Norio
    • Department of Material Chemistry, Graduate School of Engineering, Kyoto Univeresity
    • OH Hyeong kwon
    • Department of Material Chemistry, Graduate School of Engineering, Kyoto Univeresity
    • UEDA Mitsuyoshi
    • Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto Univeresity
    • TANAKA Atsuo
    • Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto Univeresity
    • IMANISHI Yukio
    • Department of Material Chemistry, Graduate School of Engineering, Kyoto Univeresity

抄録

Polyproline, which is an amphiphilic polypeptide, was incorporated into lysozyme by the recombinant DNA technique. The hydrophobicity of lysozyme increased with the incorporation of a longer polyproline. The bactericidal activity of lysozyme against Gram-negative bacteria increased with the hydrophobicity of the enzyme.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1997(1), 65-66, 1997-01 

    The Chemical Society of Japan

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10002609188
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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