Hydrophobilization of Lysozyme by Genetic Combination with Polyproline at the Carboxyl Terminal
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- Yoshihiro Ito
- Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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- Norio Hamamatsu
- Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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- Oh Hyeong Kwon
- Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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- Mitsuyoshi Ueda
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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- Atsuo Tanaka
- Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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- Yukio Imanishi
- Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
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<jats:title>Abstract</jats:title> <jats:p>Polyproline, which is an amphiphilic polypeptide, was incorporated into lysozyme by the recombinant DNA technique. The hydrophobicity of lysozyme increased with the incorporation of a longer polyproline. The bactericidal activity of lysozyme against Gram-negative bacteria increased with the hydrophobicity of the enzyme.</jats:p>
収録刊行物
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- Chemistry Letters
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Chemistry Letters 26 (1), 65-66, 1997-01-01
Oxford University Press (OUP)
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詳細情報
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- CRID
- 1360283694086091136
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- NII論文ID
- 10002609188
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- NII書誌ID
- AA00603318
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- ISSN
- 13480715
- 03667022
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