Hydrophobilization of Lysozyme by Genetic Combination with Polyproline at the Carboxyl Terminal
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Polyproline, which is an amphiphilic polypeptide, was incorporated into lysozyme by the recombinant DNA technique. The hydrophobicity of lysozyme increased with the incorporation of a longer polyproline. The bactericidal activity of lysozyme against Gram-negative bacteria increased with the hydrophobicity of the enzyme.
- Chemistry Letters
Chemistry Letters 1997(1), 65-66, 1997-01
The Chemical Society of Japan