Hydrophobilization of Lysozyme by Genetic Combination with Polyproline at the Carboxyl Terminal
Polyproline, which is an amphiphilic polypeptide, was incorporated into lysozyme by the recombinant DNA technique. The hydrophobicity of lysozyme increased with the incorporation of a longer polyproline. The bactericidal activity of lysozyme against Gram-negative bacteria increased with the hydrophobicity of the enzyme.
- Chemistry letters
Chemistry letters 1997(1), 65-66, 1997-01
The Chemical Society of Japan