Hydrophobilization of Lysozyme by Genetic Combination with Polyproline at the Carboxyl Terminal

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  • Yoshihiro Ito
    Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
  • Norio Hamamatsu
    Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
  • Oh Hyeong Kwon
    Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
  • Mitsuyoshi Ueda
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
  • Atsuo Tanaka
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto
  • Yukio Imanishi
    Department of Material Chemistry, Graduate School of Engineering, Kyoto UniversityKyoto

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Polyproline, which is an amphiphilic polypeptide, was incorporated into lysozyme by the recombinant DNA technique. The hydrophobicity of lysozyme increased with the incorporation of a longer polyproline. The bactericidal activity of lysozyme against Gram-negative bacteria increased with the hydrophobicity of the enzyme.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 26 (1), 65-66, 1997-01-01

    Oxford University Press (OUP)

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