Synthesis, Structural Characterization, and Biological Activity of Two Different Nickel(II)Complexes Derived from N'-[1-(2-pyridyl)ethylidene]morpholine-4-carbothiohydrazide
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The reaction of Ni(OAc)<SUB>2</SUB> with <I>N</I>′-[1-(2-pyridyl)ethylidene]morpholine-4-carbothiohydrazide (HL) afforded two nickel(II) complexes, [Ni(L)<SUB>2</SUB>] (<B>1</B>) and [Ni(L)(OAc)] (<B>2</B>), depending on reaction temperature and starting molar ratio; the former was a 6-coordinate, paramagnetic complex and the latter a 4-coordinate, diamagnetic complex. X-ray analysis of the complex <B>2</B> revealed that the ligands, L and OAc, were coordinated to the central metal ion to form a square-planar geometry. The complex <B>2</B> showed enhanced antimicrobial activities against selected Gram-positive bacteria, compared with those of the ligand alone, whereas the other complex <B>1</B> showed no activity.
- Chemistry Letters
Chemistry Letters 1997(7), 609-610, 1997-07
The Chemical Society of Japan