Effects of Hydrostatic Pressure on DNA Minor Groove Binding as Studied by Restriction Endonuclease Protection Assay (REPA)

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  • Guo-Qing Tang
    Department of Polymer Science and Engineering, Kyoto Institute of TechnologyMatsugasaki, Sakyo, Kyoto
  • Naoki Tanaka
    Department of Polymer Science and Engineering, Kyoto Institute of TechnologyMatsugasaki, Sakyo, Kyoto
  • Shigeru Kunugi
    Department of Polymer Science and Engineering, Kyoto Institute of TechnologyMatsugasaki, Sakyo, Kyoto

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<jats:title>Abstract</jats:title> <jats:p>The effect of pressure on the interaction of minor groove binders with the pBR322 DNA was investigated by using the restriction endonuclease protection assay. The pressure employed alone did not provide measurable enzyme protection whereas it improved the DNA protection ability of drugs. Hydration change terms were proposed to be responsible for the observed pressure effect.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 26 (8), 747-748, 1997-08-01

    Oxford University Press (OUP)

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