Determination of the Optical Purity for Serine and Threonine by Gas Chromatography on a Chiral Column

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著者

    • BENGT Fransson
    • Department of Biochemistry, University of Uppsala, Biomedical Center
    • ULF Ragnarsson
    • Department of Biochemistry, University of Uppsala, Biomedical Center

抄録

In a two-step procedure, serine and threonine were converted first to <I>N</I>-isobutoxycarbonyl-amino acid 2,2,2-trifluoroethyl esters and subsequently also to novel <I>N</I>,<I>O</I>-bis-isobutoxycarbonyl-derivatives. As such all four isomers of threonine could easily be resolved on a commercial chiral (Chirasil-<FONT SIZE=-2>D</FONT>-Val) gas chromatography column at 140 °C. A significant influence of the configuration at the β-position on the retention time was thereby observed. Similarly, improved separation was demonstrated for the two enantiomers of <I>N</I>,<I>O</I>-bis-isobutoxycarbonyl-serine isobutylamide.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1997(8), 779-780, 1997-08 

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10002613975
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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