Monoterpenoids, Potent Inducers of Apoptosis in the Cells of Marchantia polymorpha
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The cultured cells of <I>Marchantia polymorpha</I> suffered apoptosis when treated with monoterpenoids, e.g. bornyl acetate. When the apoptosis occurred, the cultured cells of <I>M. polymorpha</I> produced H<SUB>2</SUB>O<SUB>2</SUB>, which takes part in a defense reaction. The inhibitors of oxidizing agents, such as cysteine and <I>N</I>-acetylcysteine, had an apparent effect on monoterpenoid-induced apoptosis. These results showed that monoterpenoid-induced apoptosis occurs via the production of active oxygen species, e.g. H<SUB>2</SUB>O<SUB>2</SUB>.
- Chemistry Letters
Chemistry Letters 1997(8), 837-838, 1997-08
The Chemical Society of Japan