Monoterpenoids, Potent Inducers of Apoptosis in the Cells of <i>Marchantia polymorpha</i>

  • Shunsuke Izumi
    Department of Chemistry, Faculty of Science, Hiroshima UniversityHigashi-Hiroshima
  • Yosuke Nishio
    Department of Chemistry, Faculty of Science, Hiroshima UniversityHigashi-Hiroshima
  • Osamu Takashima
    Department of Chemistry, Faculty of Science, Hiroshima UniversityHigashi-Hiroshima
  • Toshifumi Hirata
    Department of Chemistry, Faculty of Science, Hiroshima UniversityHigashi-Hiroshima

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<jats:title>Abstract</jats:title> <jats:p>The cultured cells of Marchantia polymorpha suffered apoptosis when treated with monoterpenoids, e.g. bornyl acetate. When the apoptosis occurred, the cultured cells of M. polymorpha produced H2O2, which takes part in a defense reaction. The inhibitors of oxidizing agents, such as cysteine and N-acetylcysteine, had an apparent effect on monoterpenoid-induced apoptosis. These results showed that monoterpenoid-induced apoptosis occurs via the production of active oxygen species, e.g. H2O2.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 26 (8), 837-838, 1997-08-01

    Oxford University Press (OUP)

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