Tanzawaic Acids A, B, C, and D: Inhibitors of Superoxide Anion Production from <i>Penicillium citrinum</i>

  • Makoto Kuramoto
    Advanced Instrumentation Center for Chemical Analysis, Ehime UniversityBunkyou-chou 2-5, Matsuyama
  • Kaoru Yamada
    Sagami Chemical Research CenterNishi-Ohnuma 4-4-1, Sagamihara
  • Mayumi Shikano
    Sagami Chemical Research CenterNishi-Ohnuma 4-4-1, Sagamihara
  • Kazunaga Yazawa
    Sagami Chemical Research CenterNishi-Ohnuma 4-4-1, Sagamihara
  • Hirokazu Arimoto
    Department of Chemistry, Faculty of Science, Shizuoka UniversityOhya, Shizuoka
  • Tomoyuki Okamura
    Department of Chemistry, Faculty of Science, Shizuoka UniversityOhya, Shizuoka
  • Daisuke Uemura
    Department of Chemistry, Faculty of Science, Shizuoka UniversityOhya, Shizuoka

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<jats:title>Abstract</jats:title> <jats:p>Tanzawaic acids have been isolated from Penicillium citrinum and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analyses of 1H–1H coupling constants and NOE data. Tanzawaic acid B (GS-1302-1) significantly inhibits superoxide anion production in human neutrophils.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 26 (9), 885-886, 1997-09-01

    Oxford University Press (OUP)

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