New Analogs of the Pyripyropene Family of ACAT Inhibitors via <i>α</i>-Pyrone Fragmentation and <i>γ</i>-Acylation/Cyclization

• Rika Obata

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Toshiaki Sunazuka

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Zhiming Tian

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Hiroshi Tomoda

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Yoshihiro Harigaya

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Satoshi Omura

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University5-9-1 Shirokane, Minato-ku, Tokyo

• Amos B Smith

  Department of Chemistry, Monell Chemical Senses Center, and Laboratory for Research on the Structure of Matter, University of PennsylvaniaPhiladelphia, Pennsylvania 19104, U.S.A

抄録

The pyridine moiety of pyripyropene A was replaced with other aromatic and heteroaromatic substituents via α-pyrone degradation followed by dienolate γ-acylation and in situ cyclization.

収録刊行物

• Chemistry Letters

  Chemistry Letters 26 (9), 935-936, 1997-09-01

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360846644039550336
• NII論文ID: 10002615104
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.1997.935
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/26/9/935/56074188/cl.1997.935.pdf
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