Synthesis and Ion Channel Formation of Novel Cyclic Peptides Containing a Non-natural Amino Acid

  • Hitoshi Ishida
    Inoue Photochirogenesis Project, ERATO, JST4-6-3 Kamishinden, Toyonaka
  • Kiyoshi Donowaki
    Department of Molecular Chemistry, Faculty of Engineering, Osaka University2-1 Yamada-oka, Suita
  • Yoshihisa Inoue
    Inoue Photochirogenesis Project, ERATO, JST4-6-3 Kamishinden, Toyonaka
  • Zhi Qi
    Department of Physiology, Nagoya University School of Medicine65 Tsurumai, Showa, Nagoya
  • Masahiro Sokabe
    Department of Physiology, Nagoya University School of Medicine65 Tsurumai, Showa, Nagoya

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<jats:title>Abstract</jats:title> <jats:p>A series of novel cyclic peptides possessing an alternate natural / non-natural amino acid sequence were prepared from l-alanine and 5-(N-acylamino)-3-aminobenzoic acid with a long acyl chain. Upon examination by the voltage clamp method, membranes composed of the synthetic cyclic peptides with varying ring sizes and side-chain lengths were found to form cation selective channels with a conductance of ca. 9 pS in aqueous KCl (500 mM).</jats:p>

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  • Chemistry Letters

    Chemistry Letters 26 (9), 953-954, 1997-09-01

    Oxford University Press (OUP)

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