Synthesis and Ion Channel Formation of Novel Cyclic Peptides Containing a Non-natural Amino Acid
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A series of novel cyclic peptides possessing an alternate natural / non-natural amino acid sequence were prepared from <FONT SIZE=-2>L</FONT>-alanine and 5-(<I>N</I>-acylamino)-3-aminobenzoic acid with a long acyl chain. Upon examination by the voltage clamp method, membranes composed of the synthetic cyclic peptides with varying ring sizes and side-chain lengths were found to form cation selective channels with a conductance of <I>ca</I>. 9 pS in aqueous KCl (500 mM).
- Chemistry Letters
Chemistry Letters 1997(9), 953-954, 1997-09
The Chemical Society of Japan