Synthesis and Ion Channel Formation of Novel Cyclic Peptides Containing a Non-natural Amino Acid

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著者

    • DONOWAKI Kiyoshi
    • Department of Molecular Chemistry, Faculty of Engineering, Osaka University
    • INOUE Yoshihisa
    • Inoue Photochirogenesis Project, ERATO, JST, Department of Molecular Chemistry, Faculty of Engineering, Osaka University
    • QI Zhi
    • Department of Physiology, Nagoya University School of Medicine

抄録

A series of novel cyclic peptides possessing an alternate natural / non-natural amino acid sequence were prepared from <FONT SIZE=-2>L</FONT>-alanine and 5-(<I>N</I>-acylamino)-3-aminobenzoic acid with a long acyl chain. Upon examination by the voltage clamp method, membranes composed of the synthetic cyclic peptides with varying ring sizes and side-chain lengths were found to form cation selective channels with a conductance of <I>ca</I>. 9 pS in aqueous KCl (500 mM).

収録刊行物

  • Chemistry letters

    Chemistry letters 1997(9), 953-954, 1997-09

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10002615228
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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