Compressibility and Volume Changes of Lysozyme Due to Guanidine Hydrochloride Denaturation

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著者

    • KAMIYAMA Tadashi
    • Department of Materials Science, Faculty of Science, Hiroshima University
    • GEKKO Kunihiko
    • Department of Materials Science, Faculty of Science, Hiroshima University

抄録

The apparent specific volume and adiabatic compressibility of lysozyme largely decreased upon guanidine hydrochloride denaturation. These results demonstrate that a large amount of amino acid residues exposes accompanying an increase in hydration and a decrease in the internal cavity. Both parameters deviated from the two-state transition curves, suggesting noncooperative disruption of the compactness and the secondary structure.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1997(10), 1063-1064, 1997-10 

    The Chemical Society of Japan

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10002616131
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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