A High Sequence Variety in the Immunoglobulin C_α Hinge Region among Old World Monkeys

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Immunoglobulin Cα gene encodes a constant region of heavy-chain of IgA antibody, and the hinge region is located between CH1 domain and CH2 domain. The hinge region functions to increase efficiency of antigen binding by varying distance between two antigen recognition sites. The constant region of IgA has been considered to be conservative, but we previously reported that immunoglobulin Cα genes of great apes showed evolutionary hypervariability mainly in the hinge region (Kawamura and others, 1990). To know whether this hypervariability is also the case among Old World monkeys, we carried out PCR-SSCP analysis for macaque, baboon, and leaf monkey. The result clearly showed evolutionary hypervariability in the hinge region among Old World monkeys. Adding to this inter-species variability, intra-species variabilities were also observed in multiple species such as rhesus macaque, crab-eating macaque, Assamese macaque, and hamadryas baboon. Furthermore, polymorphism was likely shared by multiple macaque species (trans-species polymorphism). These results suggest the indispensability of hypervariability in the hinge region for these animals. Some kind of positive selection, like the overdominance at the MHC loci (Klein and others, 1993) might be responsible for this hypervariability.

収録刊行物

  • Anthropological science : journal of the Anthropological Society of Nippon  

    Anthropological science : journal of the Anthropological Society of Nippon 106(1), 31-39, 1998-03 

    The Anthropological Society of Nippon

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各種コード

  • NII論文ID(NAID)
    10002618493
  • NII書誌ID(NCID)
    AA10915022
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09187960
  • NDL 記事登録ID
    4448577
  • NDL 雑誌分類
    ZS1(科学技術--人類学)
  • NDL 請求記号
    Z54-J370
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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