Distribution of Group-Specific Component/Vitamin D-Binding Protein Alleles in Southwestern Japan and Geographical Clines of Allele Frequencies in Japanese Populations.

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  • Ago Kazutoshi
    Department of Legal Medicine, Faculty of Medicine, Kagoshima University
  • Yuasa Isao
    Department of Legal Medicine, Tottori University School of Medicine
  • Tsuganezawa Osao
    Department of Legal Medicine, Faculty of Medicine, Kagoshima University

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To scrutinize the geographical clines of allele frequencies of the group-specific component/vitamin-D binding protein (GC) system in Japan, the GC types in nine populations of southwestern Japan including Okinawa were determined. The frequencies of the common alleles in the island populations, especially, Yakushima and Miyako were found to be scattered more extensively than those in the populations of the mainland Japan. GC*1A2 was polymorphic in all populations except in the southwesternmost islands, Miyako and Ishigaki. The geographical clines of GC*1F, GC*1S and GC*2 frequencies are discussed in connection with the migration of the Yayoi era.

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