Separation of Baicalein from Baicalin by Means of Solvent Extraction.

• Kitazaki Hironori

  Production Technology Department, Tsumura & Co.

• Ishimaru Masayuki

  Production Technology Department, Tsumura & Co.

• Inoue Katsutoshi

  Department of Applied Chemistry, Saga University

• Yoshida Kumiko

  Department of Applied Chemistry, Saga University

Bibliographic Information

Other Title

• 溶媒抽出法によるバイカレイン／バイカリンの分離
• ヨウバイ チュウシュツホウ ニヨル バイカレイン バイカリン ノ ブンリ

Abstract

In this work, solvent extraction behaviors of some commercial extractants such as tri-n-octylphosphine oxide (TOPO), Cyanex 923 and Cyanex 925 for baicalein and baicalin decocted from Suctellaria root, which is a crude drug, were examined to elucidate their mutual separation by solvent extraction. Baicalein was extracted selectively by trialkylphosphine oxides over baicalin. From analyses of the extraction mechanism, the equilibrium constant of extraction reaction and enthalpy change were evaluated. A porous resin impregnated with Cyanex 923 in XAD-7 was prepared to remove baicalein from baicalin by using a column packed with the resin. Baicalein was able to be completely removed by this column operation.

Journal

• KAGAKU KOGAKU RONBUNSHU

  KAGAKU KOGAKU RONBUNSHU 22 (2), 287-293, 1996

  The Society of Chemical Engineers, Japan

Keywords

• Solvent Extraction
• Baicalein
• Baicalin
• TOPO
• Cyanex 925
• Cyanex 923

Details

• CRID: 1390282679486563712
• NII Article ID: 10002668324
• NII Book ID: AN00037234
• DOI: 10.1252/kakoronbunshu.22.287
• COI: 1:CAS:528:DyaK28Xhs12ltb0%3D
• ISSN: 13499203
• ISSN: 0386216X
• ISSN: http://id.crossref.org/issn/0386216X
• NDL BIB ID: 3936988
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3936988
• Web Site: http://www.jstage.jst.go.jp/article/kakoronbunshu1975/22/2/22_2_287/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed