Activity of Nucleic Acids and Peptides at High Pressure
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For last few years we have been interested in high pressure effects on biological molecules especially nucleic acids. We have found that DNA having consecutive pirymidine: purine nucleotide sequences change their conformation from Bto Z-form. Also synthetic oligoribonucleotides change their from A to Z, but at high pressure and in the presence of high salt concentration. Transfer ribonucleic acid specific for phenylalanine can be specifically aminoacylated at high pressure in the absence of aminoacyl-tRNA synthetase and ATP. tRNA charged at high pressure is a correct substrate for ribosomal protein synthesis and also catalyses peptide synthesis in vitro.
- The Review of High Pressure Science and Technology
The Review of High Pressure Science and Technology 7, 1303-1305, 1998
The Japan Society of High Pressure Science and Technology