Preparation of Biodegradable Microcapsules with (W/O/W) Emulsion in Solvent Evaporation.

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  • (W/O/W)複合エマルションを用いた液中乾燥法による生分解性マイクロカプセルの調製
  • W O W フクゴウ エマルション オ モチイタ エキチュウ カンソウホウ ニ

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Abstract

Preparation of biodegradable microcapsules with poly (3 HB-co-3 HV) was performed by the (W/O/W) emulsion-solvent evaporation method. At first, (W/O) emulsion was prepared by dispersing an aqueous ascorbic acid magnesium salt solution into the organic solution consisting of poly (3 HB-co-3 HV), hexaglicerine ricynoreic acid and 1, 2-dichloroethane. Then, (W/O/W) emulsion was prepared by dispersing the (W/O) emulsion into the outer aqueous phase consisting of decaglicerinericynoreic mono lauric acid and polyvinylalcohol. Microcapsules with porous surfaces were formed by solvent evaporation. The characteristics of microcapsules were found to be controlled by operating conditions such as solvent evaporation rate, dispersion stabilizer and concentration of poly (3 HB-co-3 HV).

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