Safety Assessment of Landfill by Mutagenicity Test.

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  • バイオアッセイ　　変異原性試験による廃棄物埋立地の安全性評価
  • ヘンイ ゲンセイ シケン ニ ヨル ハイキブツ ウメタテチ ノ アンゼンセイ

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Abstract

Recently, the influence of chemicals such as carcinogens and endocrine disrupters on the ecosystem has become a serious problem in Japan. Attention has, therefore, gathered around a bioassay including a genotoxicity (mutagenicity) test. We focused on a mutagenicity related with carcinogenicity as a safety assessment index of landfill and have been investigating the mutagens in waste and leachate since 1986. This paper provides a summary of the results of our investigation. The main results are shown below.<BR>1) The mutagens in leachate are effectively adsorbed on Sep-Pak CSP 800 in lower pH (pH 2) .<BR>2) Most mutagens in leachate are a direct mutagen induced frameshift mutation which is detected by usingS. typhimuriumTA 98 without S9, so that we can simplify the mutagenicity test.<BR>3) The fate of mutagens in landfill depends on aerobic biodegradation ; the more the landfill layer is aerobic, the faster the degradation of mutagens.<BR>4) The problems to be solved are to establish a detection method for hazardous nongenotoxic chemicals, to decide whether premutagens should be included in the mutagens from the viewpoint of risk assessment or not, and to identify the mutagens.

Journal

  • Waste Management Research

    Waste Management Research 9 (5), 394-403, 1998

    Japan Society of Material Cycles and Waste Management

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