バイオメディカル　　マイクロダイアリシス・サンプリング法に用いる表面処理透析膜のグルコース透過特性のｉｎ　ｖｉｖｏ評価

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  • Biomedical Engineering. Evaluation of Glucose Permeability of Surface-Treated Dialysis Membrane for Microdialysis Sampling Method by in vivo Experiments.
  • マイクロ ダイアリシス サンプリングホウ ニ モチイル ヒョウメン ショリ ト

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A sensor implanted into the subcutaneous tissue has a problem in terms of long-term stability. By using a microdialysis method, glucose in the extracellular tissue fluid is recovered into the dialysate and can be easily analyzed outside the human body. The purpose of this paper is to develop a microdialysis probe with a higher recovery and a biocompatible dialysis membrane for continuous sensing of glucose in subcutaneous tissue. Long-term stability in in vivo experiments was studied by using various hollow polymer membranes such as regenerated cellulose, cellulose acetate, cellulose triacetate, polymethyl methacrylate, ethylene vinyl alcohol and surface-treated membrane such as regenerated cellulose coated with Nafion or MPC. The mass-transfer coefficient of the dialysis membrane was obtained from the recovery of glucose. The recovery of glucose with the uncovered membrane decreased clearly after three days in in vivo and in vitro experiments. The membranes coated with Nafion or MPC maintained a higher recovery than the uncoated membrane did in a six-day in vivo experiment. A flexible microdialysis probe is successfully developed for continuous monitoring of glucose in subcutaneous tissues for long-term clinical application.

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