Biomedical Engineering. Relationship between Blood Compatibility and Nonthrombogenic Polymer Surfaces.
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- UCHIDA KATSUMI
- Department of Chemical Engineering, Waseda University
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- WAKI MASAHIRO
- Department of Chemical Engineering, Waseda University
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- SAKAI KIYOTAKA
- Department of Chemical Engineering, Waseda University
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- NOJIRI CHISATO
- Terumo Corporation R&D Center
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- KIDO TAKAYUKI
- Terumo Corporation R&D Center
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- SUGIYAMA TOMOKO
- Terumo Corporation R&D Center
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- ISHIHARA KAZUHIKO
- Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
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- NAKABAYASHI NOBUO
- Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
Bibliographic Information
- Other Title
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- バイオメディカル 抗血栓性材料における血液‐材料界面の解析
- コウ ケッセンセイ ザイリョウ ニ オケル ケツエキ ザイリョウ カイメン
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Abstract
Hypotheses proposed to design nonthrombogenic polymer surfaces include, 1) phase-separated microdomain surfaces, 2) hydrophilic surfaces, 3) bioactive molecule incorporated surfaces and 4) biomembrane-like surfaces. In order to clarify the relationship between these surface design and their blood compatibility, we evaluated platelet adhesion and complement activation on these surfaces using an epifluorescent video microscopy (EVM) system, and analyzed adsorbed proteins on these surfaces using a sheep chronic left ventricular assist device (LVAD) model. The results are as follows ; 1) thrombogenesis depends on the amount of adhered platelet at the initial contact with blood on the surfaces, 2) nonthrombogenicity of the blood contacting surfaces is dependent on the thickness, conformation and components of adsorbed proteins on the surfaces and 3) complement activation is not correlated with the amount of adhered platelet.
Journal
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- KAGAKU KOGAKU RONBUNSHU
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KAGAKU KOGAKU RONBUNSHU 24 (2), 217-221, 1998
The Society of Chemical Engineers, Japan
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Details 詳細情報について
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- CRID
- 1390282679486361984
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- NII Article ID
- 10002835263
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- NII Book ID
- AN00037234
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- ISSN
- 13499203
- 0386216X
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- NDL BIB ID
- 4424751
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed