Changes in urinary excretion of pyridinium cross-links during Spacelab-J.

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  • Seo Hisao
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
  • Itoh Takayasu
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
  • Murata Yoshiharu
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
  • Ohmori Sachiko
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
  • Kambe Fukushi
    Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
  • Mohri Mamoru
    Faculty of Physical Education, Chukyo University, Tokodate, Kaizu-cho, Toyota 470-0348, Japan
  • Sekiguchi Chiharu
    Faculty of Physical Education, Chukyo University, Tokodate, Kaizu-cho, Toyota 470-0348, Japan
  • Matsui Nobuo
    Space Utilization Promotion Department, Office of Space Utilization Systems National Space Development Agency of Japan, Tsukuba Space Center, Sengen, Tsukuba, Ibaraki 305-0047, Japan

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  • Changes in Urinary Excretion of Pyridin

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Abstract

In SLJ⁄L-1 we proposed to study three major objectives. They were; 1. hormonal changes associated with fluid and electrolyte metabolism, 2. the effect of space flight on the circadian rhythms of endocrine and metabolic systems, 3. the changes in the indices of the bone and muscle metabolism during space flight. In this report, the changes in the bone metabolism during Spacelab-J will be presented with a special emphasis on urinary excretion of pyridinium cross-links. Timed urine samples from three Japanese payload specialists were obtained for 3 days from May 19 to 21, 1991 (one year before the launch = L-1 year). Immediately before the launch (L-3 to L-0), urine samples were obtained from a payload specialist who was on board the Space Shuttle Endeavor (PS). During the inflight period (flight from September 3 to 10 in 1992), urine samples from the PS were collected by using Urine Monitoring System (UMS). After the landing, they were obtained from the PS for three days (R+0 - R+2). Various parameters related to bone metabolism such as hydroxyproline, pyridinium cross-links and calcium were determined. It was noted that excretion of hydroxyproline decreased during the preflight periods when compared with that in the control L-1 year period. The average excretory rate during control period was 846.2 ±198.7 μg⁄hour (mean ± SD), while those in the preflight 474.6 ± 171.1 μg⁄hour, suggesting the diminished collagen intake during the preflight period. Average excretion rate of pyridinium cross-links during the first 4 mission days (MD0 - MD3) was similar to that of preflight and control L-1 year period. However, it was significantly increased during the last 4 mission days (MD4 - MD7). It returned to the preflight level during postflight days (R+0 - R+2). Increased urinary excretion of calcium during the last 4 mission days were also observed. These results suggest that increase in bone resorption could occur during relatively short stay in microgravity.

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