Precision Polymerization and Polymers I. Characterization and Bioactivities of Chitin and Chitosan Regulated Their Degree of Deacetylation.

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  • 精密重合・精密合成高分子Ｉ　　脱アセチル化度を制御したキチン，キトサンの生物活性
  • ダツ アセチルカド オ セイギョシタ キチン キトサン ノ セイブツ カッセイ

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Abstract

Chitin and chitosan, a heterocopolymer of N-acetyl-β-D-glucosamine (GlcNAc) and D-glucosamine (GlcN), were investigated from the following standpoint: 1) the determination of degree of deacetylation (DDA), 2) the sequence reguladty, 3) the relationship between the bioactivities and DDA. DDA of a deacetylated chitin (DAC) or a partially N-acetylated chitosan (PAC) can be determined accurately by infrared spectroscopic method using a calibration line obtained by ratios of intensity of the 1560cm-1 absorption band as a determination band to that of the 1070cm-1 or 1030cm-1 absorption band as an internal standard against DDA determined another method. The sequence regularity of GlcNAc and GlcN residues in DAC and PAC prepared under homogenoous or heterogeneous conditions was investigated by nitrous acid deamination and Bernoullian statistical analysis. These results indicate a random distribution of GlcNAc residues in the DAC and PAC. The relationship between bioactivities, antibacteria and polymorphonuclear cell activation, and DDA of DAC and PAC were also investigated. The bioactivities were strongly depemded on the DDA.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 54 (10), 621-631, 1997

    The Society of Polymer Science, Japan

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