アパタイト表面における骨組織形成ならびにその石灰化について

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  • Formation and Calcification of BoneTissue on the Surface of Apatite Ceramics
  • アパタイト ヒョウメン ニ オケル ホネ ソシキ ケイセイ ナラビニ ソノ セ

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Apatite implantation into the jaw bones of adult dogs was carried out histologically to check the biocompatibility. <BR>At 5 days, the bone matrix formation began on the surface of tne apatite. In the 10-day specimen, the area of bone formation on the surface of the apatite was enlarged and at the same time the calcification began. <BR>TEM observation of this condition revealed the differentiation of the osteoblast around the surface of the apatite, followed by the formation of collagen fibers and osteoid with many small round deposits of bone crystals and matrix vesicles in an isolated from. <BR>A thin layer without the collagen fibers was observed on the surface of the apatite. In such areas, the plate-shaped crystals began to deposit directly on the surface of the apatite. In the area where the bone formation was rapid at 10 days, gradually the isolated crystal deposits became larger by the further deposition of crystals in the longitudinal direction to the surrounding collagen fibers and fused with each other, and fused further with the crystal layer without the collagen fibers on the surface of the apatite. Finally, a wide calcified layer was formed on the apatite. <BR>Subsequently, the crystals on and around the apatite grew gradually and exhibited a condition similar to that of the normal mature bone at 30 days.

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