Activation of aniline by extracts from plants and induction of chromosomal damages in Chinese hamster ovary cells

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Activation of aniline by plant extracts was studied by a chromosomal damage induction assay in Chinese hamster ovary (CHO) cells in vitro. Extracts from roots of <i>Vicia faba</i> activated aniline and the activation caused increases in chromosomal aberrations (CAs) and endoreduplicated cells (ERCs), but did not cause sister-chromatid exchanges (SCEs). Extracts from <i>Pisum sativum</i> and <i>Lactuca sativa</i>, however, did not activate aniline. All <i>C</i>-hydroxylated metabolites of aniline, <i>o</i>-aminophenol, <i>m</i>-aminophenol and <i>p</i>-aminophenol, induced not only CAs but also SCEs in CHO cells. These results show that the pathway for aniline activation by <i>Vicia</i> extracts is by means other than the <i>C</i>-hydroxylation.<br>

収録刊行物

  • Genes & genetic systems

    Genes & genetic systems 71(5), 319-322, 1996-10

    The Genetics Society of Japan

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各種コード

  • NII論文ID(NAID)
    10003760260
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13417568
  • NDL 記事登録ID
    4163735
  • NDL 雑誌分類
    ZR1(科学技術--生物学)
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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