EFFECT OF ULTRASOUND ON RATE OF DRUG ABSORPTION THROUGH SKIN

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著者

    • YAMASHITA Akihiro
    • Department of Biochemical Engineering and Science, College of Computer Science and Systems Engineering, Kyushu Institute of Technology
    • HIRAI Yoshiaki
    • Department of Biochemical Engineering and Science, College of Computer Science and Systems Engineering, Kyushu Institute of Technology
    • TOJO Kakuji
    • Department of Biochemical Engineering and Science, College of Computer Science and Systems Engineering, Kyushu Institute of Technology

抄録

Ultrasound frequency of 1.0 MHz was applied with an ultrasound probe to a piece of excised hairless mouse skin for enhancing the rate of prednisolone (PN) transfer across the skin <I>in vitro</I>. The results showed that the rate of PN transfer through the intact skin was greatly enhanced according to the application time of ultrasound. Although ultrasound increases the temperature adjacent to the probe, its effect on enhancing the rate of PN transfer through the intact skin was found to be insignificant. Pretreatment experiments in which ultrasound was applied before performing normal permeation experiments were also performed. Although ultrasound was not applied in the normal permeation experiments following the pretreatment, the results showed that pretreatment also enhanced the rate of PN transfer through the intact skin in proportion to the period of pretreatment time. This implied that the ultrasound might have changed some structures of the skin. Pretreatment of 1800 s or more made the rate of PN transfer through the intact skin close to that through tape-stripped skin. This was caused either by a morphology change of the skin or by enlargement of the diameters of some follicles, or by both.

収録刊行物

  • Journal of chemical engineering of Japan

    Journal of chemical engineering of Japan 29(5), 812-816, 1996-10-20

    The Society of Chemical Engineers, Japan

参考文献:  7件中 1-7件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10003815430
  • NII書誌ID(NCID)
    AA00709658
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00219592
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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