Novel Direct Preparation of n - Butyl 2 - Amino - 2 - deoxy - β - D - glucopyranoside from Chitosan and n - Butanol Using Biocatalyst
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<I>n</I>-Butyl 2-amino-2-deoxy-<I>β</I>-<FONT SIZE=-2>D</FONT>-glucopyranoside (C<SUB>4</SUB>GlcN) was prepared by the novel direct transglycosylation reaction of chitosan and <I>n</I>-butanol using the resting cells of <I>Penicillium funiculosum</I> KY616 as the enzyme source of exo-<I>β</I>-<FONT SIZE=-2>D</FONT>-glucosaminidase. Using this strain, a versatile synthetic intermediate, C<SUB>4</SUB>GlcN, was prepared in a yield of 210 mg/g chitosan when chitosan and <I>n</I>-butanol were incubated at a temperature of 30 °C and pH 4 for 2 d.
- Chemistry Letters
Chemistry Letters 1999(5), 373-374, 1999-05-05
The Chemical Society of Japan