Synthesis of (-)-Gleenol via C-H Insertion Reaction of Alkylidenecarbene
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A spiro sesquiterpene alcohol, (−)-gleenol (1) was synthesized from (−)-l-menthol in 16 steps, using the C-H insertion reaction of the alkylidenecarbene as the key step. The absolute configuration of (−)-1 was determined to be 1S, 6R, 7S, 10R.
- Chemistry Letters
Chemistry Letters 1998(8), 739-740, 1998-08-05
The Chemical Society of Japan