Helical Stereoregular Artificial Glycoconjugate Polymers Based on Poly (phenylacetylene) Backbone : Synthesis and Molecular Recognition with Lectin

この論文にアクセスする

この論文をさがす

著者

    • MATSUURA Kazunori
    • Department of Molecular Design and Department of Biotechnology, Graduate School of Engineering, Nagoya University
    • FURUNO Shi-ichi
    • Department of Molecular Design and Department of Biotechnology, Graduate School of Engineering, Nagoya University
    • KOBAYASHI Kazukiyo
    • Department of Molecular Design and Department of Biotechnology, Graduate School of Engineering, Nagoya University

抄録

Stereoregular poly(phenylacetylene)s bearing pendant lactose and cellobiose moiety were synthesized by polymerization of β-N-glycosylated 4-ethynylbenzamides with [Rh(nbd)Cl]<SUB>2</SUB> (nbd=norbornadiene) as initiator. The glycoconjugate polymer possessed alternating double bond backbone with cis-transoidal regioregularity and helical conformation. Inhibition assay of hemagglutination revealed that galactose-specific lectin efficiently bound to the stereoregular helical glycopolymer bearing lactose, but the binding was not so strong as that of the corresponding flexible glycoconjugate polystyrene.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1998(8), 847-848, 1998-08-05 

    The Chemical Society of Japan

参考文献:  17件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10004484891
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ