Efficient Synthesis of Enantiopure 1,2-Bis (hydroxymethyl)-3,3-difluorocyclopropane Derivatives through Lipase-Catalyzed Reaction
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Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3,3-difluorocyclopropane was converted to the corresponding monoacetate through Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomeric excess.
- Chemistry Letters
Chemistry Letters 1998(9), 903-904, 1998-09-05
The Chemical Society of Japan