In vivo Simultaneous Monitoring by Pt - disk Microelectrodes of Intracerebral Hydrogen Peroxide and Dopamine in Rats

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A technique was developed for simultaneous monitoring of temporal changes in hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) and dopamine (DA) levels by using Pt-disk microelectrodes (φ 30 μm). H<SUB>2</SUB>O<SUB>2</SUB> and DA were determined by differential double-pulse amperometry (for H<SUB>2</SUB>O<SUB>2</SUB>; 1st step, 750 mV, 1000 ms; 2nd step, 1100 mV, 1000 ms: for DA; 1st step, 150 mV, 600 ms; 2nd step, 250 mV, 50 ms). The electrode for H<SUB>2</SUB>O<SUB>2</SUB> or DA is capable of determining each target substance and these substances do not interfere with each other. For an <I>in vivo</I> application, the electrodes were implanted into the striatum of rats and used successfully to monitor intrastriatal changes in H<SUB>2</SUB>O<SUB>2</SUB> and DA simultaneously after intraperitoneal injection of methamphetamine while the animals were moving freely.

収録刊行物

  • Chemistry letters

    Chemistry letters 1999(6), 497-498, 1999-06-05

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10004486204
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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