A Facile Synthesis of Optically Active 1,1,1 - Trifluoro - 3 - alkyn - 2 - ols by Stereospecific Substitution of Optically Active 1 - Benzyloxy - 2,2,2 - trifluoroethyl Tosylate with Lithium Alkynyltriethylaluminates
Optically active 1-benzyloxy-2,2,2-trifluoroethyl tosylate reacts with various lithium alkynyltriethylaluminates to give optically active 2-benzyloxy-1,1,1-trifluoro-3-alkynes selectively and stereospecifically with inversion of configuration. Thus, the reaction provides with a novel method for the preparation of various optically active 1,1,1-trifluoro-3-alkyn-2-ols.
- Chemistry letters
Chemistry letters 1999(6), 529-530, 1999-06-05
The Chemical Society of Japan