DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment
Access this Article
Search this Article
To determine the effects of the space environment on gene instability from the point of view of human health for long-term stays in space, we have studied the formation of DNA strand breaks and the induction of gene expression in mammalian cells. We previously measured DNA damage in human cultured cells and the accumulation of a tumor suppressor gene product, p53, in muscle and skin of rats after space flight, and the relative importance of microgravity and space radiation in causing these effects remains to be clarified. Our results suggest that the p53 pathway may play a role in safeguarding genomic stability against the stressful space environment. We review here the present knowledge on cellular stress signaling and present our space experimental data. The importance of the stress response to the space environment is also discussed.
- Biological Sciences in Space
Biological Sciences in Space 13(2), 82-87, 1999-06
Japanese Society for Biological Sciences in Space