DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment

この論文にアクセスする

この論文をさがす

著者

抄録

To determine the effects of the space environment on gene instability from the point of view of human health for long-term stays in space, we have studied the formation of DNA strand breaks and the induction of gene expression in mammalian cells. We previously measured DNA damage in human cultured cells and the accumulation of a tumor suppressor gene product, p53, in muscle and skin of rats after space flight, and the relative importance of microgravity and space radiation in causing these effects remains to be clarified. Our results suggest that the p53 pathway may play a role in safeguarding genomic stability against the stressful space environment. We review here the present knowledge on cellular stress signaling and present our space experimental data. The importance of the stress response to the space environment is also discussed.

収録刊行物

  • 宇宙生物科学 = Biological sciences in space  

    宇宙生物科学 = Biological sciences in space 13(2), 82-87, 1999-06 

    日本宇宙生物科学会

参考文献:  35件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

被引用文献:  1件

被引用文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10004491652
  • NII書誌ID(NCID)
    AN10164806
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    09149201
  • NDL 記事登録ID
    4847075
  • NDL 雑誌分類
    ZR1(科学技術--生物学) // ZM33(科学技術--宇宙科学)
  • NDL 請求記号
    Z18-2504
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ