Some Theoretical Considerations on Calorimetrically Determined Bactericidality of Antimicrobial Drugs and Its Concentration Dependence.

• Wirkner Sandra

  Lab. of Biophysical Chemistry, Div. of Applied Biochemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture Univ.

• Takahashi Katsutada

  Lab. of Biophysical Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture Univ. Lab. of Non-destructive and Non-Invasive Analysis, Keihanna Veterans Circle

Abstract

Based on the theory to characterize the bacteriostatic and bactericidal actions of drugs proposed by Takahashi, further theoretical considerations were attempted on the bactericidality of a drug and its concentration dependence. An index term to show the bactericidality as a function of drug concentration was defined and the concentration dependence was graphically drawn on the basis of inhibitory parameters determined calorimetrically. The result was obtained that if the parameters characterizing the apparent cooperativity in drug actions obtained from the growth rate is different from those obtained from the growth retardation, the bactericidality changes largely depending on the drug concentration. The result was also found to be consistent with the observation for some drugs where the SCI plot defined previously does not show a straight line, but exhibits an upward curvature.

Journal

• Netsu Sokutei

  Netsu Sokutei 27 (4), 179-185, 2000

  The Japan Society of Calorimetry and Thermal Analysis

Details

• CRID: 1390001205087375232
• NII Article ID: 130003658687
• NII Article ID: 10004571317
• NII Book ID: AN00199597
• DOI: 10.11311/jscta1974.27.179
• ISSN: 18841899
• ISSN: 03862615
• NDL BIB ID: 5463279
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5463279
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed