Ca^<2+>結合タンパク質S100Bの結晶構造と分子認識機構 A Novel Mode of Target Recognition Suggested by the 2.0 A Structure of Holo S100B from Bovine Brain

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抄録

The three-dimensional structure of holo S100B from bovine brain has been determined at 2.0 Å resolution by X-ray diffraction. The dimeric S100B molecule is formed by non-covalent interactions between large hydrophobic surface on both S100β subunits. There are two EF-hand motifs per S100β subunit, each of which binds one calcium ion. We observe, in the calcium-bound structure, dramatic changes in the conformation of the terminal helices, from the compact structure in the apo form to a more extended form upon binding calcium. This conformational change suggests a novel mode of target recognition of S100B.

収録刊行物

  • 日本結晶学会誌  

    日本結晶学会誌 41(6), 347-352, 1999-12-31 

    The Crystallographic Society of Japan

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各種コード

  • NII論文ID(NAID)
    10004674054
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03694585
  • NDL 記事登録ID
    4987826
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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