Conformational and Orientational Switching of Uridine Derivatives by Borates

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We have demonstrated for the first time that the syn-anti orientation of 5′-amino-5′-deoxyuridine (1b) can readily be switched by adding borate as an extermal controlling factor. In borate added phosphate buffer, the syn/anti ratio of 1b dramatically increased with increasing borate concentration. This unique syn preference is most probably driven by the cooperative action of cyclic esterification of the 1b's 2′,3′-cis-diol with borate and of hydrogen-bonding formation between 2-carbonyl oxygen and 5′-amino proton.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1998(10), 1025-1026, 1998-10-05 

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10004700115
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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