Enantioselective Borohydride 1,4-Reduction of α,β-Unsaturated Carboxamides Using Optically Active Cobalt (II) Complex Catalysts
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The enantioselective borohydride reduction catalyzed by cobalt(II) complex was successfully applied to 1,4-reduction of β,β-disubstituted α,β-unsaturated carboxamides. In the presence of less than 1 mol% of optically active aldiminato cobalt(II) complex catalyst, the corresponding carboxamides were obtained in high yields with high enantiomeric excesses.
- Chemistry Letters
Chemistry Letters 1998(11), 1129-1130, 1998-11-05
The Chemical Society of Japan