Chiral Zirconium-Catalyzed Asymmetric Mannich-Type Reactions Using Acylhydrazones as Imine Equivalents

この論文にアクセスする

この論文をさがす

著者

    • KOBAYASHI Shu
    • Graduate School of Pharmaceutical Science, The University of Tokyo, CREST
    • ISHITANI Haruro
    • Department of Applied Chemistry, Faculty of Science, Science University of Tokyo (SUT)

抄録

In the presence of a catalytic amount of a new zirconium catalyst, prepared from zirconium(IV) t-butoxide and (R)-3,3′-dibromo-1,1′-bi-2-naphthol, 4-trifluoromethylbenzoylhydrazones reacted with silyl enolates to afford the corresponding adducts, β-N′-acylhydrazinocarbonyl compounds, in good yields with high enantiomeric excesses. Reductive cleavage of the nitrogen-nitrogen bond of the hydrazino compound using samarium diiodide gave a chiral β-aminocarbonyl compound. In addition, the hydrazino compound was also successfully converted to chiral β-lactam and pyrazolidinone derivatives.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1998(11), 1131-1132, 1998-11-05 

    The Chemical Society of Japan

参考文献:  23件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10004700924
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ