α-β Structural Transition of Short Oligopeptides by Water/Organic Solvent Titration
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Designed two peptides, Ac-Trp-Lys-Ala<SUB>13</SUB>-Lys-NH<SUB>2</SUB> and Ac-Trp-Lys-Ala<SUB>15</SUB>-Lys-NH<SUB>2</SUB> were synthesized by utilizing natural L-amino acids and were capable of performing a structural transition from β-sheet to α-helix. The α–β transition of the designed peptides was induced by interstrand hydrophobic interaction. This shows that our designed peptides may be an model system for the elucidation of misfolding and transformation mechanism of pathogenic proteins.
- Chemistry Letters
Chemistry Letters 1999(7), 637-638, 1999-07-05
The Chemical Society of Japan