Enantioselective Synthesis of Pyrrolydinonyl Thymine Nucleoside Analogues
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Enantioselective synthesis of a novel kind of optically active nucleoside analogues from natural malic acid is described. In the given nucleoside analogues the tetrahydrofuran ring is replaced by a pyrrolidinonyl ring bearing both a primary and a secondary hydroxy groups which could be useful for the preparation of novel oligonucleotides. Assay of the prepared nucleoside analogues showed non-activity against virus.
- Chemistry Letters
Chemistry Letters 1999(7), 687-688, 1999-07-05
The Chemical Society of Japan