Highly Diastereoselective Aldol Synthesis from α-Iodo Ketones in Aqueous Media
Highly diastereoselective aldol synthesis from α-iodo ketones was promoted under aqueous conditions by a distannane system, (<I>n</I>-Bu<SUB>3</SUB>Sn)<SUB>2</SUB>, <I>n</I>-Bu<SUB>2</SUB>SnF<SUB>2</SUB> and HMPA. Aqueous solutions of acetaldehyde, formaldehyde and pivaraldehyde were applicable to give β-hydroxy ketones effectively.
- Chemistry letters
Chemistry letters 1999(7), 689-690, 1999-07-05
The Chemical Society of Japan