Microbial 7-OH Epimerisation of Bile Acids

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  • Mariangela Dean
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy
  • Giancarlo Fantin
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy
  • Marco Fogagnolo
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy
  • Alessandro Medici
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy
  • Paola Pedrini
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy
  • Silvia Poli
    Dipartimento di Chimica, Università di FerraraVia L. Borsari 46, I-44100 Ferrara , Italy

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Abstract

<jats:title>Abstract</jats:title> <jats:p>The microbial 7-OH epimerisation of cholic and chenodeoxycholic acids with Xanthomonas maltophilia CBS 827.97 to ursocholic and ursodeoxycholic acids with scarsity of oxygen is described. With normal pressure of oxygen the 7-ketocholic and the 7-ketochenodeoxycholic acids are obtained. No biotransformation is achieved in anaerobic conditions.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 28 (7), 693-694, 1999-07-01

    Oxford University Press (OUP)

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