A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus

この論文にアクセスする

この論文をさがす

著者

    • HAYASHIDA Osamu
    • Institute for Fundamental Research of Organic Chemistry, Kyushu University
    • GUO Chao-Tan
    • Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
    • SUZUKI Yasuo
    • Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences

抄録

A calix[4]resorcarene-based macrocyclic octa(sialic acid) derivative <B>1d</B> was prepared. It forms complexes with such guests as rose bengal in water. It forms a closely packed monolayer on an SPR sensor chip; a sialo-targeting lectin is readily adsorbed on the saccharide residues exposed to bulk water. Compound <B>1d</B> also inhibits the hemagglutination of human erythrocytes and also cytopathic effect of MDCK (Madine-Darby canine kidney) cells mediated by human influenza A viruses at concentrations of 5-50 μM.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1999(12), 1259-1260, 1999-12-05 

    The Chemical Society of Japan

参考文献:  23件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

被引用文献:  1件

被引用文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10004703787
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    OTR
  • ISSN
    03667022
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
ページトップへ