A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus
A calixresorcarene-based macrocyclic octa(sialic acid) derivative <B>1d</B> was prepared. It forms complexes with such guests as rose bengal in water. It forms a closely packed monolayer on an SPR sensor chip; a sialo-targeting lectin is readily adsorbed on the saccharide residues exposed to bulk water. Compound <B>1d</B> also inhibits the hemagglutination of human erythrocytes and also cytopathic effect of MDCK (Madine-Darby canine kidney) cells mediated by human influenza A viruses at concentrations of 5-50 μM.
- Chemistry letters
Chemistry letters 1999(12), 1259-1260, 1999-12-05
The Chemical Society of Japan