A Macrocyclic Sialic Acid Cluster as a Host, as an Adsorbate, and as a Ligand for Lectin and Virus

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  • Kazuhisa Fujimoto
    Institute for Fundamental Research of Organic Chemistry, Kyushu University, CREST, Japan Science and Technology Corporation (JST)Hakozaki, Higashi-ku, Fukuoka
  • Osamu Hayashida
    Institute for Fundamental Research of Organic Chemistry, Kyushu University, CREST, Japan Science and Technology Corporation (JST)Hakozaki, Higashi-ku, Fukuoka
  • Yasuhiro Aoyama
    Institute for Fundamental Research of Organic Chemistry, Kyushu University, CREST, Japan Science and Technology Corporation (JST)Hakozaki, Higashi-ku, Fukuoka
  • Chao-Tan Guo
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical SciencesYada, Shizuoka
  • Kazuya I-P Jwa Hidari
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical SciencesYada, Shizuoka
  • Yasuo Suzuki
    Department of Biochemistry, University of Shizuoka School of Pharmaceutical SciencesYada, Shizuoka

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<jats:title>Abstract</jats:title> <jats:p>A calix[4]resorcarene-based macrocyclic octa(sialic acid) derivative 1d was prepared. It forms complexes with such guests as rose bengal in water. It forms a closely packed monolayer on an SPR sensor chip; a sialo-targeting lectin is readily adsorbed on the saccharide residues exposed to bulk water. Compound 1d also inhibits the hemagglutination of human erythrocytes and also cytopathic effect of MDCK (Madine-Darby canine kidney) cells mediated by human influenza A viruses at concentrations of 5-50 μM.</jats:p>

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  • Chemistry Letters

    Chemistry Letters 28 (12), 1259-1260, 1999-12-01

    Oxford University Press (OUP)

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