Synthesis of Water-soluble Oxidized Chitosan Derivatives and Their Biological Activity

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Oxidized chitosan derivatives were prepared by CrO<SUB>3</SUB> oxidation of chitosan followed by <I>N</I>-acetylation, and their effect on canine polymorphonuclear cells was evaluated. The water-solubility of oxidized chitosan derivatives (DS: 0.10-0.28) in the range of pH 1-13 was controlled by the degree of <I>N</I>-acetylation (DA), and the oxidized chitosan derivatives of DA 76 and 83% were soluble in water at the neutral pH range. Effect of oxidized chitosan derivatives on canine polymorphonuclear cells (PMNs) was estimated by the reported chemiluminescence (CL) technique, and the peak count of CL induced by zymosan after the treatment of PMNs with oxidized chitosan derivatives was lower than that induced by only zymosan.

収録刊行物

  • Chemistry letters  

    Chemistry letters 1999(12), 1285-1286, 1999-12-05 

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10004703998
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    OTR
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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