3-Isopropylidenemalic Acid:A Mechanism-based Inhibitor of 3-Isopropylmalate Dehydrogenase
3-Isopropylidenemalic acid (<B>1</B>) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, <B>1</B> appeared to be a mechanism-based inhibitor (<I>K</I><SUB>I</SUB> = 60.2 μM) for IPMDH as deduced from the time-dependent and kinetic analyses.
- Chemistry letters
Chemistry letters 1999(12), 1313-1314, 1999-12-05
The Chemical Society of Japan